Integrated analysis of multidimensional omics data on cutaneous melanoma prognosis
نویسندگان
چکیده
منابع مشابه
Computational methods for integrated analysis of omics and pathway data
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1. GENERAL INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. A COMPUTATIONAL PLATFORM TO MAINTAIN AND MIGRATE MANUAL FUNCTIONAL ANNOTATIONS FOR BIOCYC DATABASES 9 Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Background . . . . . . . . . . . . ....
متن کاملPrognosis of Sentinel Node Staged Patients with Primary Cutaneous Melanoma
BACKGROUND This study investigated survival probabilities and prognostic factors in sentinel lymph node biopsy (SLNB) staged patients with cutaneous melanoma (CM) with the aim of defining subgroups of patients who are at higher risk for recurrences and who should be considered for adjuvant clinical trials. METHODS Patients with primary CM who underwent SLNB in the Department of Dermatology, U...
متن کاملInflammation markers in cutaneous melanoma - edgy biomarkers for prognosis
There is a fine balance between inflammation and tumorigenesis. While environmentally induced inflammatory condition can precede a malignant transformation, in other cases an oncogenic change of unknown origin can induce an inflammatory microenvironment that promotes the development of tumors. Regardless of its origin, maintaining the inflammation milieu has many tumor-promoting effects. As a r...
متن کاملMicroRNA and cutaneous melanoma: from discovery to prognosis and therapy.
Melanoma incidence and associated mortality continue to increase worldwide. The lack of treatments with durable responses for stage IV melanoma may be due, at least in part, to an incomplete understanding of the molecular mechanisms that regulate tumor initiation and/or progression to metastasis. Recent evidence supports miRNA dysregulation in melanoma impacting several well-known pathways such...
متن کاملIntegrated Multiple “-omics” Data Reveal Subtypes of Hepatocellular Carcinoma
Hepatocellular carcinoma is one of the most heterogeneous cancers, as reflected by its multiple grades and difficulty to subtype. In this study, we integrated copy number variation, DNA methylation, mRNA, and miRNA data with the developed "cluster of cluster" method and classified 256 HCC samples from TCGA (The Cancer Genome Atlas) into five major subgroups (S1-S5). We observed that this classi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genomics
سال: 2016
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2016.04.005